FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis
Weiwei Shi, Xinyi Tang, Fei Yang, Han Yin, Quan Zhou, Fangyue Sun, Shanbo Ding, Udo Jeschke, Lin Peng · 2026
Read FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis by Weiwei Shi, Xinyi Tang, Fei Yang, Han Yin, Quan Zhou, Fangyue Sun, Shanbo Ding, Udo Jeschke, Lin Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400612.txt.
Description
Weiwei Shi and co-authors link, in 2026, a senescence program in womb lining cells to the chronic inflammation of endometriosis. In this condition, womb-like tissue grows outside the uterus and causes pelvic pain and inflammation. Aged, senescent cells release a cocktail of inflammatory signals, and the team asked whether that cocktail is at work here.
Single-cell gene data revealed a subgroup of lining stromal cells carrying the senescence signature in both normal-position lining and lesions. A gene switch called FOSL2 ran abnormally high in those cells. Forcing it up aged the cells and released the inflammatory cocktail, while lowering it reversed both. Fluid from high-FOSL2 cells also drew in and reprogrammed immune cells. A hormone-driven pathway upstream controlled the switch.
Catalog record
| CREATOR | Weiwei Shi, Xinyi Tang, Fei Yang, Han Yin, Quan Zhou, Fangyue Sun, Shanbo Ding, Udo Jeschke, Lin Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47895 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |