The P2X7 receptor: insights from the murine monoclonal antibody clone L4
Ronald Sluyter, Amal Elhage, Rachael Bartlett, Debbie Watson, Leanne Stokes, Kristen K. Skarratt, Stephen J. Fuller, Ben J. Gu · 2026
Read The P2X7 receptor: insights from the murine monoclonal antibody clone L4 by Ronald Sluyter, Amal Elhage, Rachael Bartlett, Debbie Watson, Leanne Stokes, Kristen K. Skarratt, Stephen J. Fuller, Ben J. Gu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400550.txt.
Description
Ronald Sluyter and colleagues trace, in 2026, what one antibody tool has revealed about the P2X7 receptor, a channel on immune cells that opens when ATP appears outside cells. The antibody, clone L4, was the first published against the human form of the receptor. The article also honors a late pioneer of the field.
Clone L4 can block the channel and pore, and has been used to label the receptor in flow analysis, microscopy and tissue staining across blood cells and cancer lines. Pulling the receptor down with the antibody exposed partner molecules and unexpected roles, such as engulfing particles. Recently the antibody was shown to kill receptor-bearing cells via the complement system, a possible new way to curb its activity.
Catalog record
| CREATOR | Ronald Sluyter, Amal Elhage, Rachael Bartlett, Debbie Watson, Leanne Stokes, Kristen K. Skarratt, Stephen J. Fuller, Ben J. Gu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43804 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |