MMP8 exacerbates sepsis-induced pulmonary vascular leakage by disruption of endothelial VE-cadherin through ERK signalling
Yaojun Peng, Qiyan Wu, Yuyu Liu, Di Jing, Yang Bai, Haiyan Zhu · 2026
Read MMP8 exacerbates sepsis-induced pulmonary vascular leakage by disruption of endothelial VE-cadherin through ERK signalling by Yaojun Peng, Qiyan Wu, Yuyu Liu, Di Jing, Yang Bai, Haiyan Zhu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400542.txt.
Description
Yaojun Peng and team show, in 2026, that an enzyme called MMP8 helps sepsis pry open lung blood vessels. Sepsis can wreck the vessel lining, letting fluid leak into the lungs and other organs, a major driver of death. The enzyme was known to rise in sepsis, but its role at the barrier was unclear.
MMP8 rose in treated vessel cells and in lungs of septic mice. Raising or lowering it in cells changed how leaky the lining became under inflammatory attack. Blocking it in mice eased lung leakage, organ injury and death. Mechanistic work traced a chain: the enzyme activated a signaling protein, which freed cutting enzymes that destroyed a key cell-to-cell anchor. Patient blood levels also ran high, especially with chest fluid.
Catalog record
| CREATOR | Yaojun Peng, Qiyan Wu, Yuyu Liu, Di Jing, Yang Bai, Haiyan Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59162 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |