Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity
Abdulmohsin J. Alamoudi · 2026
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Description
Abdulmohsin J Alamoudi reviews, in 2026, plant compounds that may calm overactive NMDA receptors in the brain. These receptors help learning and memory, but overstimulation floods nerve cells with calcium. That excitotoxic process drives damage in stroke, epilepsy, brain injury and degenerative disease.
Compounds from several plant families are surveyed, including vitexin, ginsenosides, quercetin, resveratrol, huperzine A and bilobalide. Studies suggest they can block the receptor directly, target one of its subunits, or lower its production. Many also ease inflammation, oxidative stress and cell death pathways downstream. The author presents these natural products as a rich source for future brain-protective drug design, while noting most evidence is early and experimental.
Catalog record
| CREATOR | Abdulmohsin J. Alamoudi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53332 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |