The future objectives of the International Mouse Phenotyping Consortium (IMPC): functional evaluation of human disease-relevant cis-regulatory elements in the mouse genome
Naoki Kubo, Akiko Oguchi, Hiroshi Masuya, Takanori Amano, Akihiko Sakashita, Hideya Kawaji, Takeya Kasukawa, Shinya Oki, Shinya Ayabe, Toyoyuki Takada, Atsuo Ogura, Kimiko Inoue, Yasuhiro Murakawa, Masaru Tamura, Atsushi Yoshiki, Toshihiko Shiroishi · 2026
Read The future objectives of the International Mouse Phenotyping Consortium (IMPC): functional evaluation of human disease-relevant cis-regulatory elements in the mouse genome by Naoki Kubo, Akiko Oguchi, Hiroshi Masuya, Takanori Amano, Akihiko Sakashita, Hideya Kawaji, Takeya Kasukawa, Shinya Oki, Shinya Ayabe, Toyoyuki Takada, Atsuo Ogura, Kimiko Inoue, Yasuhiro Murakawa, Masaru Tamura, Atsushi Yoshiki, Toshihiko Shiroishi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400468.txt.
Description
Naoki Kubo and many colleagues set out, in a 2026 white paper, the next aims of the International Mouse Phenotyping Consortium. The consortium has built a large resource by knocking out genes in mice and recording the effects. Yet most disease-linked variants found in human genome scans sit outside genes, in control regions.
Those control stretches, called cis-regulatory elements, are numerous and act only in certain tissues and times, making their roles hard to predict. The paper proposes three steps: pick the most disease-relevant candidates, edit them in mice to test function directly, and form cross-field working groups. Extending the program beyond coding genes could show how control regions shape whole-body traits.
Catalog record
| CREATOR | Naoki Kubo, Akiko Oguchi, Hiroshi Masuya, Takanori Amano, Akihiko Sakashita, Hideya Kawaji, Takeya Kasukawa, Shinya Oki, Shinya Ayabe, Toyoyuki Takada, Atsuo Ogura, Kimiko Inoue, Yasuhiro Murakawa, Masaru Tamura, Atsushi Yoshiki, Toshihiko Shiroishi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |