Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming
Yoojin Seo, Ji-Su Ahn, Nhu-Nam Nguyen, Hyeon Seo Lee, Yunji Lee, Seong Hui Kim, Jeong Hyun Yu, Ji-Won Yang, Hee-Jeong Park, Hansong Lee, Tae-Hoon Shin, Byung-Chul Lee, Eui-Suk Sung, Jung-Hwan Lee, Won Kyu Kim, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Jee-Heon Jeong, Hyung-Sik Kim · 2026
Read Melatonin-inspired hybrid spheroids accelerate intestinal repair via YAP-driven fetal reprogramming by Yoojin Seo, Ji-Su Ahn, Nhu-Nam Nguyen, Hyeon Seo Lee, Yunji Lee, Seong Hui Kim, Jeong Hyun Yu, Ji-Won Yang, Hee-Jeong Park, Hansong Lee, Tae-Hoon Shin, Byung-Chul Lee, Eui-Suk Sung, Jung-Hwan Lee, Won Kyu Kim, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Jee-Heon Jeong, Hyung-Sik Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400227.txt.
Description
Yoojin Seo and colleagues engineered a living delivery system, part stem cell spheroid and part melatonin depot, that speeds intestinal healing by reviving a fetal-like repair program, in a 2026 study. Their construct fuses melatonin-loaded biodegradable microspheres with three-dimensionally cultured mesenchymal stem cells, which themselves secrete prostaglandin E2.
The hybrid spheroids kept the stem cells' paracrine output intact and survived better in vivo than plain stem cell spheroids, thanks to the melatonin's protective effect. They induced revival stem cells robustly while shielding tissue against inflammatory and oxidative insults in the dish. In a mouse colitis model, the construct accelerated mucosal healing through both arms of its design, calming inflammation and driving stem-cell-based repair, with marked clinical improvement. The authors present the biohybrid as a framework for next-generation cell therapy in inflammatory bowel disease.
Catalog record
| CREATOR | Yoojin Seo, Ji-Su Ahn, Nhu-Nam Nguyen, Hyeon Seo Lee, Yunji Lee, Seong Hui Kim, Jeong Hyun Yu, Ji-Won Yang, Hee-Jeong Park, Hansong Lee, Tae-Hoon Shin, Byung-Chul Lee, Eui-Suk Sung, Jung-Hwan Lee, Won Kyu Kim, Jung-Min Oh, Dongjun Lee, Yun Hak Kim, Jee-Heon Jeong, Hyung-Sik Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53368 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |