Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma
Jisu Park, Meiyu Qiu, Eun Jeong Cho, Sanghee Seo, Ji-Hoon Moon, Minji Kim, Hyemin Mun, Hyounji Yun, Hoewon Park, Arim Lim, Younsoo Kang, Jeong-woo Oh, Heejeong Youk, Seon-Hwan Kim, Yeongbeom Seo, Sae Min Kwon, Kyoung Su Sung, Hyuk-Jin Oh, Kyung Rae Cho, Kyungtae Yoon, Nam-Shik Kim, Se Jin Jang, Kyung Hwan Kim, Ki-Jun Yoon · 2026
Read Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma by Jisu Park, Meiyu Qiu, Eun Jeong Cho, Sanghee Seo, Ji-Hoon Moon, Minji Kim, Hyemin Mun, Hyounji Yun, Hoewon Park, Arim Lim, Younsoo Kang, Jeong-woo Oh, Heejeong Youk, Seon-Hwan Kim, Yeongbeom Seo, Sae Min Kwon, Kyoung Su Sung, Hyuk-Jin Oh, Kyung Rae Cho, Kyungtae Yoon, Nam-Shik Kim, Se Jin Jang, Kyung Hwan Kim, Ki-Jun Yoon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400186.txt.
Description
Jisu Park and colleagues grew organoids from eighteen patients' glioblastomas, in a 2026 study. The mini-tumors predict who will respond to the standard drug temozolomide better than the field's standard biomarker. The organoid lines preserved their parent tumors' appearance and genomes, and their drug sensitivity was compared with the patients' actual progression-free survival.
The organoid results correlated strongly with how long patients stayed progression-free. They beat MGMT methylation status, the one accepted predictive marker, at forecasting temozolomide response. Studying the resistant models exposed the escape routes: mismatch repair deficiency, high MGMT expression, and switched-on programs for axon growth and cell adhesion. The authors position such drug testing as a working platform for a tumor that has defeated nearly every trial drug.
Catalog record
| CREATOR | Jisu Park, Meiyu Qiu, Eun Jeong Cho, Sanghee Seo, Ji-Hoon Moon, Minji Kim, Hyemin Mun, Hyounji Yun, Hoewon Park, Arim Lim, Younsoo Kang, Jeong-woo Oh, Heejeong Youk, Seon-Hwan Kim, Yeongbeom Seo, Sae Min Kwon, Kyoung Su Sung, Hyuk-Jin Oh, Kyung Rae Cho, Kyungtae Yoon, Nam-Shik Kim, Se Jin Jang, Kyung Hwan Kim, Ki-Jun Yoon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75286 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |