Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer
Meixi Hao, Qifan Hu, Xiuqi Li, Yijun Chen, Siyuan Hou, Chunjing Han, Sijia Chen, Yanyi Li, Kaiming Li, Lingjing Xue, Lulu Zhu, Shanshan Chen, Caoyun Ju, Can Zhang · 2026
Read Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer by Meixi Hao, Qifan Hu, Xiuqi Li, Yijun Chen, Siyuan Hou, Chunjing Han, Sijia Chen, Yanyi Li, Kaiming Li, Lingjing Xue, Lulu Zhu, Shanshan Chen, Caoyun Ju, Can Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400185.txt.
Description
Meixi Hao and colleagues reprogrammed neutrophils without touching their genes, in a 2026 study aimed at breast cancer that has spread to the lungs. They trained the cells with interferon gamma and armed them with a chemo nanoparticle. The team's answer is a sequential conditioning recipe producing what they call meta-neutrophils with a locked-in antitumor character.
The interferon gamma training first fixes the cells in their cancer-killing, immune-stimulating phenotype so the tumor environment cannot flip them. Loading them with Abraxane, the albumin-bound paclitaxel formulation, adds direct cytotoxic punch. The loaded cells accumulated strongly in lung metastases in their models. Because the recipe needs no genetic modification and works regardless of donor, the authors present meta-neutrophils as a practical route toward clinical neutrophil therapy for metastatic triple-negative breast cancer.
Catalog record
| CREATOR | Meixi Hao, Qifan Hu, Xiuqi Li, Yijun Chen, Siyuan Hou, Chunjing Han, Sijia Chen, Yanyi Li, Kaiming Li, Lingjing Xue, Lulu Zhu, Shanshan Chen, Caoyun Ju, Can Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112370 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |