Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4+CD8+ T cells
Alexander K Tsai, John R Lozada, Philippa R Kennedy, David Moline, Rachana Pandey, Riley C Lyons, Christine Luo, Rulin Wang, Ali T Arafa, Elise L Femino, Sarah Zipkowitz, Alexis Figueroa, Patrick J McCann, Matthew C Dallos, Andrew Elliott, Paari Murugan, Martin Felices, Nicholas A Zorko, Badrinath R Konety, Scott M Dehm, Jeffrey S Miller, Steven S Shen, Elizabeth A Thompson, Laura A Sena, Srinivasan Yegnasubramanian, Justin Hwang, Emmanuel S Antonarakis · 2026
Read Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4+CD8+ T cells by Alexander K Tsai, John R Lozada, Philippa R Kennedy, David Moline, Rachana Pandey, Riley C Lyons, Christine Luo, Rulin Wang, Ali T Arafa, Elise L Femino, Sarah Zipkowitz, Alexis Figueroa, Patrick J McCann, Matthew C Dallos, Andrew Elliott, Paari Murugan, Martin Felices, Nicholas A Zorko, Badrinath R Konety, Scott M Dehm, Jeffrey S Miller, Steven S Shen, Elizabeth A Thompson, Laura A Sena, Srinivasan Yegnasubramanian, Justin Hwang, Emmanuel S Antonarakis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400160.txt.
Description
Alexander K Tsai and colleagues dissect an exceptional case: a man whose aggressive prostate cancer vanished completely on immunotherapy, in a 2026 report. The 67-year-old patient had locally advanced Gleason 5+5=10 cancer invading bladder and rectum. His tumor carried a rare profile, deleted MSH2 and MSH6 mismatch-repair genes and an ultrahigh mutation burden above 250 mutations per megabase. That kind of genomic instability can make checkpoint inhibitors work. Pembrolizumab produced a complete response on imaging, on pathology, and at the molecular level.
These cell groups expanded after checkpoint treatment and matured into killer profiles. The case offers a cell-level hypothesis for why a few such tumors melt away.
Catalog record
| CREATOR | Alexander K Tsai, John R Lozada, Philippa R Kennedy, David Moline, Rachana Pandey, Riley C Lyons, Christine Luo, Rulin Wang, Ali T Arafa, Elise L Femino, Sarah Zipkowitz, Alexis Figueroa, Patrick J McCann, Matthew C Dallos, Andrew Elliott, Paari Murugan, Martin Felices, Nicholas A Zorko, Badrinath R Konety, Scott M Dehm, Jeffrey S Miller, Steven S Shen, Elizabeth A Thompson, Laura A Sena, Srinivasan Yegnasubramanian, Justin Hwang, Emmanuel S Antonarakis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64320 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |