Intervening in aging and related diseases with gene therapy techniques
Mengmeng Jiang, Jing Qu, Moshi Song, Guang-Hui Liu · 2026
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Description
Mengmeng Jiang, Jing Qu, Moshi Song, and Guang-Hui Liu review how gene therapy could be turned against aging itself, in this 2026 article. Aging is the master risk factor behind most chronic disease. Instead of chasing each disease separately, the authors survey strategies that rewrite the genetic and epigenetic programs driving decline.
The toolkit they organize spans genome editing that permanently alters DNA, RNA modulation that adjusts gene output temporarily, and epigenetic reprogramming that resets a cell's age marks without changing its identity. Against the fourteen recognized hallmarks of aging, they map which genes push aging forward and which protect against it. They weigh each intervention class for durability against delivery difficulty, safety, cost, and ethics. Gene approaches promise longer-lasting effects than drugs or lifestyle change because they act programmably at the source. The review is candid that delivery efficiency and long-term outcomes remain unsolved.
Catalog record
| CREATOR | Mengmeng Jiang, Jing Qu, Moshi Song, Guang-Hui Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60090 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |