Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction
Yiming Zhong, Zhaowenbin Zhang, Shixing Huang, Ao Shen, Bei Qian, Qiang Long, Zhaoxi Qi, Xiaojun He, Yecen Zhang, Lan Chang, Wangxi Hai, Xinming Wang, Zhengwei You, Qiang Zhao, Jiang Chang, Xiaofeng Ye · 2026
Read Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction by Yiming Zhong, Zhaowenbin Zhang, Shixing Huang, Ao Shen, Bei Qian, Qiang Long, Zhaoxi Qi, Xiaojun He, Yecen Zhang, Lan Chang, Wangxi Hai, Xinming Wang, Zhengwei You, Qiang Zhao, Jiang Chang, Xiaofeng Ye (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13400144.txt.
Description
Yiming Zhong and colleagues, with Xiaofeng Ye and Jiang Chang, designed a heart attack treatment that releases zinc and copper in sequence, timed to the injury's changing biology, in this 2026 study. The team first mapped how zinc and copper levels move through the tissue over time and space after infarction.
Matching the therapy to that map meant giving each ion when the tissue's staged demands call for it. The timed regimen measurably improved cardiac function and blunted post-infarction heart failure in their models. Mechanistically, the benefit runs through PER2, a core circadian clock gene that governs cellular metabolic balance. The ion schedule works by precisely modulating it. The authors frame the approach as therapy synchronized with the wound's own timetable, a contrast to the one-shot dosing that may explain earlier ion trials' mixed record.
Catalog record
| CREATOR | Yiming Zhong, Zhaowenbin Zhang, Shixing Huang, Ao Shen, Bei Qian, Qiang Long, Zhaoxi Qi, Xiaojun He, Yecen Zhang, Lan Chang, Wangxi Hai, Xinming Wang, Zhengwei You, Qiang Zhao, Jiang Chang, Xiaofeng Ye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104664 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |