GUT MICROBIOTA ALTERATIONS IN RODENT MODELS OF CHOLESTASIS INDUCED BY BILE DUCT LIGATION: A SYSTEMATIC REVIEW
Stephane Lima CALIXTO, Ana Caroline Lopes de Paula MACEDO, Jair Adriano Kopke AGUIAR · 2026
Read GUT MICROBIOTA ALTERATIONS IN RODENT MODELS OF CHOLESTASIS INDUCED BY BILE DUCT LIGATION: A SYSTEMATIC REVIEW by Stephane Lima CALIXTO, Ana Caroline Lopes de Paula MACEDO, Jair Adriano Kopke AGUIAR (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13399934.txt.
Description
Stephane Lima Calixto and colleagues reviewed what happens to gut bacteria in rats and mice whose bile duct is tied off, the standard laboratory model of cholestasis, in this 2026 review. Following PRISMA methods, the team searched PubMed, Scopus, and Embase for bile duct ligation studies from 2020 to early 2025 that profiled the intestinal microbiome without testing treatments.
Twenty-two studies qualified, most using 16S rRNA sequencing. A consistent pattern emerged: ligation lowered microbial diversity in most studies, reshuffled community structure, and shifted the major phyla. Two organisms increased often enough that the authors read them as possible responses. The synthesis links this dysbiosis to a weaker gut barrier, more bacteria crossing into the body, and fiercer liver inflammation. Because nearly all the evidence is from animals, the authors caution that microbiome-based therapies for cholestasis still need proper human trials.
Catalog record
| CREATOR | Stephane Lima CALIXTO, Ana Caroline Lopes de Paula MACEDO, Jair Adriano Kopke AGUIAR |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |