BILIARY SLUDGE-ASSOCIATED ACUTE PANCREATITIS: CLINICAL SPECTRUM, DIAGNOSIS, AND MANAGEMENT

Mingqi SU, Yayun XIE, Ji CHEN · 2026

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Description

Mingqi Su, Yayun Xie, and Ji Chen review the pancreatitis caused by biliary sludge, the gritty microcrystal material that routine scans cannot see, in this 2026 article. The authors searched PubMed, Embase, and the Cochrane Library and built a clinical framework from trials, guidelines, and consensus statements.

The mechanism they describe is a continuum: stone-forming bile, a sluggish gallbladder, and mucin glue produce sludge. Its crystals transiently block the shared outflow channel and injure its lining with bile acids, sparking the pancreatic attack. Ordinary ultrasound and CT are poor at finding sludge, while endoscopic ultrasound beats even MRCP for spotting microlithiasis. The framework grades diagnostic confidence as definite, probable, or presumptive. It crosses that grade with attack severity to decide who gets MRCP or endoscopic ultrasound, who needs duct-clearing ERCP, and when gallbladder removal fits. The authors argue the structured approach should cut preventable recurrences.

Catalog record

CREATORMingqi SU, Yayun XIE, Ji CHEN
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE38335
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13399933

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