MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY
Isadora Brandão PELUCIO, Carla MALAGUTI, Túlio Medina Dutra de OLIVEIRA, Karoline Maria de Souza Marques CHITARRA, Maria Cristina Vasconcellos FURTADO, Júlio Maria Fonseca CHEBLI · 2026
Read MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY by Isadora Brandão PELUCIO, Carla MALAGUTI, Túlio Medina Dutra de OLIVEIRA, Karoline Maria de Souza Marques CHITARRA, Maria Cristina Vasconcellos FURTADO, Júlio Maria Fonseca CHEBLI (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13399930.txt.
Description
Isadora Brandão Pelucio and colleagues compared antibiotics for Clostridioides difficile infection in people who also have inflammatory bowel disease, in a 2026 review and meta-analysis. Searching five databases through October 2024 under PRISMA rules, the team gathered studies that compared regimens head to head in adults with both conditions.
Nine studies covering 643 patients qualified. Recurrence struck 17.4 percent of patients on metronidazole against 8.2 percent on vancomycin. Pooling the four studies that allowed it leaned the same way, an odds ratio of 0.55 favoring vancomycin, though the difference was not statistically significant and the studies disagreed considerably with each other. Deaths were few and similar across groups, and every colectomy occurred in colitis patients. The authors conclude that vancomycin may protect higher-risk IBD patients from recurrence, but the evidence is thin and patchy, and prospective trials designed for this population are the real need.
Catalog record
| CREATOR | Isadora Brandão PELUCIO, Carla MALAGUTI, Túlio Medina Dutra de OLIVEIRA, Karoline Maria de Souza Marques CHITARRA, Maria Cristina Vasconcellos FURTADO, Júlio Maria Fonseca CHEBLI |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18829 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |