Rare Cutaneous Metastasis From Esophageal Squamous Cell Carcinoma
Sarah Hsin Cheng, Yen‐Shuo Huang, Chi‐En Hsiao, Hui‐Hua Hsiao · 2026
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Description
Sarah Hsin Cheng and colleagues report a rare skin metastasis from esophageal squamous cell carcinoma in a 2026 case. During his fifth treatment course, examiners found a hard, reddened nodule on his left upper back. The painless lump had no discharge or ulceration, and its nature was unclear enough that the team biopsied it.
Under the microscope the skin held keratinizing squamous cell carcinoma growing through the dermis, with tumor cells invading small vessels. No abnormality showed in the surface epidermis, a pattern supporting metastasis rather than a new skin primary. The diagnosis proved an ominous turn. Soon afterward he arrived at the emergency department with severe headache, vomiting, and altered consciousness, and scans showed multiple brain metastases among other deposits. The authors note that esophageal cancer almost never seeds the skin, so they urge biopsy of new nodules in such patients rather than watchful waiting.
Catalog record
| CREATOR | Sarah Hsin Cheng, Yen‐Shuo Huang, Chi‐En Hsiao, Hui‐Hua Hsiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3894 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |