Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang · 2026
Read Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis by Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13399620.txt.
Description
Restoring blood flow to a starved heart saves muscle but also triggers a fresh wave of cell death, including a form driven by iron and fat oxidation. Yan-Bo Zhao and co-authors tested whether a plant flavonoid could blunt that wave in this 2026 study. The work used heart cells stressed in dishes and a mouse model of heart artery blockage and release.
The compound raised cell survival, pushed a master defense switch into the cell nucleus, and lifted a protective enzyme downstream of it. That chain is a known shield against the iron-driven death. Natural compounds with both antioxidant and anti-inflammatory action are attractive add-ons to standard heart attack care, if their effects survive testing in larger animals and people.
Catalog record
| CREATOR | Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |