A lysosomal escape‐enabled endoplasmic reticulum‐targeting BODIPY photothermal agent for enhanced tumor ablation
Shaoyang Shi, Yanbing Cao, Jiexuan Zuo, Qiushi Li, Xiaolong Zeng, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng · 2026
Read A lysosomal escape‐enabled endoplasmic reticulum‐targeting BODIPY photothermal agent for enhanced tumor ablation by Shaoyang Shi, Yanbing Cao, Jiexuan Zuo, Qiushi Li, Xiaolong Zeng, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13399612.txt.
Description
Shaoyang Shi and a team of chemists designed a light-activated dye that heats tumors from inside a specific organelle, reporting in 2026. The group built their agent on a BODIPY scaffold, adding a trifluoromethyl group and a p-toluenesulfonyl tag that steers it to the endoplasmic reticulum, the cell's protein-folding workshop. The dye was packed into coated nanoparticles.
The particles absorbed near-infrared light strongly, peaking at 780 nanometers, and converted 80.3 percent of it to heat in the efficiency measurements reported. Inside cells they escaped the lysosomes and gathered in the ER, where focused heating triggered severe organelle stress and apoptotic death. In animal tests, mild laser light at 760 nanometers ablated tumors effectively while systemic toxicity stayed negligible. The authors present the design as a general strategy: give such an agent an escape route plus an organelle address, and it can kill at gentler temperatures.
Catalog record
| CREATOR | Shaoyang Shi, Yanbing Cao, Jiexuan Zuo, Qiushi Li, Xiaolong Zeng, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24592 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |