Monotherapy versus combination therapy for treatment of carbapenem-resistant Acinetobacter baumannii complex infections: results from an observational study
Sidnei Umberto Bertholdi, João Paulo Telles, Igor Mochiutti de Melo, Daniela Kallíope de Sá Paraskevopoulos, Carolina Hikari Yamada, Allan Homero dos Santos, Felipe Francisco Tuon, João Silva de Mendonça, Augusto Yamaguti, Thaís Guimarães · 2026
Read Monotherapy versus combination therapy for treatment of carbapenem-resistant Acinetobacter baumannii complex infections: results from an observational study by Sidnei Umberto Bertholdi, João Paulo Telles, Igor Mochiutti de Melo, Daniela Kallíope de Sá Paraskevopoulos, Carolina Hikari Yamada, Allan Homero dos Santos, Felipe Francisco Tuon, João Silva de Mendonça, Augusto Yamaguti, Thaís Guimarães (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13399235.txt.
Description
Sidnei Umberto Bertholdi and colleagues compared single-drug against combined treatment for infections caused by Acinetobacter baumannii that resist carbapenem drugs, in a 2026 study from two Brazilian hospitals. This germ resists nearly all standard drugs and haunts intensive care units, causing bloodstream infections and pneumonia in ventilated patients, with very high death rates. Whether adding drugs helps has stayed unsettled.
The study covered 123 patients treated between 2018 and 2022, most in intensive care. Three quarters received combined therapy, usually built around polymyxin antibiotics; sulbactam-based regimens accounted for 16.3 percent of cases, as the authors report. Death rates were nearly the same for both strategies, at 73.3 percent for single-drug and 73.1 percent for combined treatment in the reported figures. In adjusted analysis, only the APACHE II score predicted death. The authors suspect illness severity, not drug strategy, drove the outcomes, and they call for future trials.
Catalog record
| CREATOR | Sidnei Umberto Bertholdi, João Paulo Telles, Igor Mochiutti de Melo, Daniela Kallíope de Sá Paraskevopoulos, Carolina Hikari Yamada, Allan Homero dos Santos, Felipe Francisco Tuon, João Silva de Mendonça, Augusto Yamaguti, Thaís Guimarães |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31170 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |