Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge · 2026
Read Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction by Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13398862.txt.
Description
Maren Jinks and co-authors watch liver cells' chemistry unravel dose by dose under hydrogen peroxide attack. Their 2026 study exposes HepG2 liver cells to low, medium and high peroxide levels and reads the fallout with NMR metabolomics, inside and outside the cells. Such lab liver models, paired with chemical profiling, promise toxicology answers without animal testing.
Damage widened with dose: a few metabolites shifted at low exposure, while the highest level disturbed most of those measured. Pretreating cells with rifampicin to wake their cytochrome P450 enzymes, normally sleepy in this cell line, changed how the high dose played out. The work shows dose and metabolic readiness together shape what a toxin appears to do.
Catalog record
| CREATOR | Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37197 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |