Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann · 2026
Read Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer by Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13398714.txt.
Description
Malagola and co-authors show, in 2026, that losing the proton-sensing receptor TDAG8 accelerates colon cancer in mice. TDAG8 sits on immune cells, senses acidity, and is a risk gene for inflammatory bowel disease, whose sufferers face higher colorectal cancer risk. The team compared TDAG8-deficient and normal mice in two cancer models: transplanted MC38 tumors and the chemical AOM/DSS protocol. The protocol used four cycles of 3 percent DSS in drinking water.
In both models, deficient mice developed greater tumor burden, with larger, heavier, and more tumors than controls. Their tumors carried more DNA damage sites and heavier influx of neutrophils, monocytes, and macrophages, the phagocyte family, alongside an elevated CD4-to-CD8 T-cell ratio measured by flow cytometry. The authors conclude TDAG8 restrains tumor-promoting inflammation, and they propose drugs that boost the receptor as colorectal cancer therapeutics, the opposite strategy to blocking it.
Catalog record
| CREATOR | Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |