Association of sTREM2 and YKL-40 With Alzheimer’s Disease Progression: A Systematic Review
Rasha Omer Babiker Mohamed, Abubaker M Elamin, Sara Salim Ali Ahmed, Salma B Mahmuod, Hounayda Abdelrahman Mohamed Hamid, Rawan Awad Amer Ahmed, May Medhat Aboaly · 2026
Read Association of sTREM2 and YKL-40 With Alzheimer’s Disease Progression: A Systematic Review by Rasha Omer Babiker Mohamed, Abubaker M Elamin, Sara Salim Ali Ahmed, Salma B Mahmuod, Hounayda Abdelrahman Mohamed Hamid, Rawan Awad Amer Ahmed, May Medhat Aboaly (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13398357.txt.
Description
Rasha Omer Babiker Mohamed and co-authors review two fluid markers of brain inflammation as trackers of Alzheimer's disease. Their 2026 systematic review gathers studies from 2021 to 2025 on sTREM2, shed from microglia, and YKL-40, tied to astrocyte activity. Inflammation sits at the core of Alzheimer's, yet how these markers pair with amyloid and tau damage, and at which stage they help, stayed unclear.
Following PRISMA 2020 rules, four databases plus citation chasing fed the review, with two independent screeners after duplicates were stripped by software. The synthesis weighs whether either marker forecasts decline well enough to guide trials or care. Gaps in staging and prognosis evidence are named plainly for the next wave of studies.
Catalog record
| CREATOR | Rasha Omer Babiker Mohamed, Abubaker M Elamin, Sara Salim Ali Ahmed, Salma B Mahmuod, Hounayda Abdelrahman Mohamed Hamid, Rawan Awad Amer Ahmed, May Medhat Aboaly |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53916 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |