Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes · 2026
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Description
Two water channel proteins in pancreatic cancer balls are tested by Catarina Pimpão and co-authors in work dated 2026. This cancer kills late-found and drug-proof. The channels, AQP3 and AQP5, run high in such tumors. The team grew two tumor lines as balls and blocked or silenced the channels. Ball size, area, and life signs were tracked.
Blocking AQP3 shrank balls and cut their life signs. Silencing either channel in one line shrank balls and killed more cells. Roundness shifted in the second line under the block. Both channels now stand as drug targets worth chase.
Catalog record
| CREATOR | Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |