Zizybeoside II From Jujube Fructus Prolongs Lifespan and Mitigates Alzheimer's Disease Progression in Caenorhabditis elegans Through HSF‐1/HSP‐16.2 Pathway
Pu‐Sen Li, Yang Liu, Meng‐Rui Zhao, Ya‐Qiong Zhu, Ying‐Xin Shi, Meng‐Dan Jing, Xue‐Wei Hu, Chao‐Huai Jiang, Xu‐Dong Liu, Yi‐Lin You, Chang‐Jing Wu, Na‐Na Bie, Xiao‐Meng Liu · 2026
Read Zizybeoside II From Jujube Fructus Prolongs Lifespan and Mitigates Alzheimer's Disease Progression in Caenorhabditis elegans Through HSF‐1/HSP‐16.2 Pathway by Pu‐Sen Li, Yang Liu, Meng‐Rui Zhao, Ya‐Qiong Zhu, Ying‐Xin Shi, Meng‐Dan Jing, Xue‐Wei Hu, Chao‐Huai Jiang, Xu‐Dong Liu, Yi‐Lin You, Chang‐Jing Wu, Na‐Na Bie, Xiao‐Meng Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13398156.txt.
Description
Pu-Sen Li and colleagues single out one compound from jujube fruit and test it against ageing and Alzheimer's-like damage in tiny worms. Their 2026 study isolates zizybeoside II from jujube extract, a fruit eaten as food and medicine in China for thousands of years. Earlier work showed the whole extract stretched worm lifespan, raising the question of which ingredient does the work.
Worms given the compound lived longer while keeping their fertility, movement and stress resistance as they aged. In worms bred to model Alzheimer's disease, it eased paralysis and behaviour faults driven by amyloid protein. The effect runs through a heat-shock defence pathway led by HSF-1 and its partner HSP-16.2, pointing to a food-derived candidate for healthy ageing research.
Catalog record
| CREATOR | Pu‐Sen Li, Yang Liu, Meng‐Rui Zhao, Ya‐Qiong Zhu, Ying‐Xin Shi, Meng‐Dan Jing, Xue‐Wei Hu, Chao‐Huai Jiang, Xu‐Dong Liu, Yi‐Lin You, Chang‐Jing Wu, Na‐Na Bie, Xiao‐Meng Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |