Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice
Ashley L Fernandes, Laurine Lang, Jürgen Klar, Anja Giese, Alexander Ehrmann, Rupert Busch, Hannah Auwerx, Christoph Daniel, Nati Hernando, Isabel Rubio‐Aliaga, Carsten A Wagner · 2026
Read Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice by Ashley L Fernandes, Laurine Lang, Jürgen Klar, Anja Giese, Alexander Ehrmann, Rupert Busch, Hannah Auwerx, Christoph Daniel, Nati Hernando, Isabel Rubio‐Aliaga, Carsten A Wagner (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13396815.txt.
Description
Fernandes and colleagues measured how human kidneys reclaim phosphate in 2026, comparing tissue from newborns and adults with mouse kidneys. Phosphate is a mineral the body needs in steady amounts, and the kidney acts as gatekeeper by taking it back from urine. Drugs that block this reclaiming step are a hoped-for way to lower phosphate in kidney disease.
Using tiny membrane sacs from kidney tissue and radioactive tracers, the team separated the work of three transporter proteins that carry phosphate into cells. In mice, one transporter, SLC34A1, did about 80 percent of the work. In adult humans it did only about 40 percent, while a second transporter, SLC34A3, did far more than in mice. A third route outside this protein family handled about one fifth in every group. The species gap warns that mouse results may mislead drug design for people.
Catalog record
| CREATOR | Ashley L Fernandes, Laurine Lang, Jürgen Klar, Anja Giese, Alexander Ehrmann, Rupert Busch, Hannah Auwerx, Christoph Daniel, Nati Hernando, Isabel Rubio‐Aliaga, Carsten A Wagner |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |