Engineering human Gut-on-a-Chip culturomics for predictive pharmacomicrobiomics of first-pass metabolism
Itsuma Nagao, Hyun Jung Kim · 2026
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Description
Itsuma Nagao writes a 2026 perspective on gut-on-a-chip systems that grow human intestinal microbes alongside gut tissue, and what they could do for drug testing. Many swallowed drugs are changed by the gut before reaching the blood. This first-pass effect varies by person, which helps explain why the same dose acts differently across patients.
Chips that pair a living gut lining with a cultured microbial community let researchers measure host, microbe, and drug acting on each other directly. Nagao argues such platforms could feed predictive models of a person's gut ecosystem, guiding dose choices and flagging drug-microbe clashes that current rules-based testing barely covers.
Catalog record
| CREATOR | Itsuma Nagao, Hyun Jung Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52941 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |