Spatial proteomics and cell-cell crosstalk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis
Giulia Orlandi, Diletta Overi, Rosanna Di Tinco, Alessandra Pisciotta, Giulia Bertani, Sara De Biasi, Stefano Leone, Vincenzo Cardinale, Matteo Franchitto, Selenia Miglietta, Teresa De Luca, Ludovica Ceci, Paolo Onori, Savino Paradiso, Antonio Franchitto, Domenico Alvaro, Guido Carpino, Eugenio Gaud · 2026
Read Spatial proteomics and cell-cell crosstalk analysis reveal PD-L1 and IL-6 interaction in human primary sclerosing cholangitis by Giulia Orlandi, Diletta Overi, Rosanna Di Tinco, Alessandra Pisciotta, Giulia Bertani, Sara De Biasi, Stefano Leone, Vincenzo Cardinale, Matteo Franchitto, Selenia Miglietta, Teresa De Luca, Ludovica Ceci, Paolo Onori, Savino Paradiso, Antonio Franchitto, Domenico Alvaro, Guido Carpino, Eugenio Gaud (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13396724.txt.
Description
Giulia Orlandi and others map PD-L1 and IL-6 cross-talk in hardening bile-duct illness in a 2026 study. This long defense-led bile-duct illness scars bile tubes without rest, yet the lining-defense cross-talk that drives it was half mapped.
Space protein maps of six sick and five sound bile ducts joined single-cell gene data. A dish model of bile lining cells with fired-up blood defense cells bared how PD-L1 and IL-6 signals meet at the tissue seam. The paper pins defense checkpoints in bile-duct harm that drug teams may soon aim at.
Catalog record
| CREATOR | Giulia Orlandi, Diletta Overi, Rosanna Di Tinco, Alessandra Pisciotta, Giulia Bertani, Sara De Biasi, Stefano Leone, Vincenzo Cardinale, Matteo Franchitto, Selenia Miglietta, Teresa De Luca, Ludovica Ceci, Paolo Onori, Savino Paradiso, Antonio Franchitto, Domenico Alvaro, Guido Carpino, Eugenio Gaud |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |