A novel small molecule remyelination therapy for multiple sclerosis
Yan Yang, Brain Bai, Lars J. S. Knutsen, Richard J. Hamlyn, Qiao-Ling Cui, Jack Antel, Wendy Macklin, Satish Medicetty, Bruce D. Trapp · 2026
Read A novel small molecule remyelination therapy for multiple sclerosis by Yan Yang, Brain Bai, Lars J. S. Knutsen, Richard J. Hamlyn, Qiao-Ling Cui, Jack Antel, Wendy Macklin, Satish Medicetty, Bruce D. Trapp (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13396656.txt.
Description
Yan Yang and co-authors screened 20,000 brain-targeted small molecules for one that could push immature cells to become the myelin-making cells lost in multiple sclerosis. Their 2026 study found a lead compound, CN045, active at just 40 nanomolar in mouse precursor cells, beating the known promoter triiodothyronine.
Myelin is the insulation whose loss slows nerve signals in this disease. The compound coaxed mouse and human precursor cells to wrap engineered fibers in myelin-like sheaths. In mice whose brains had been stripped of myelin by a toxin pairing, it raised regrowth in both white and gray matter. The molecule enters the brain and showed low toxicity to cells.
Catalog record
| CREATOR | Yan Yang, Brain Bai, Lars J. S. Knutsen, Richard J. Hamlyn, Qiao-Ling Cui, Jack Antel, Wendy Macklin, Satish Medicetty, Bruce D. Trapp |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53583 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |