Trifluridine/tipiracil enhances radiation-induced abscopal effects and augments PD-1 blockade in gastric cancer
Tetsuya Asakawa, Jun Kinoshita, Kenta Doden, Kengo Hayashi, Saki Hayashi, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Sachiyo Nomura, Yasuhiko Yamamoto, Noriyuki Inaki · 2026
Read Trifluridine/tipiracil enhances radiation-induced abscopal effects and augments PD-1 blockade in gastric cancer by Tetsuya Asakawa, Jun Kinoshita, Kenta Doden, Kengo Hayashi, Saki Hayashi, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Sachiyo Nomura, Yasuhiko Yamamoto, Noriyuki Inaki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13396637.txt.
Description
Stomach cancer often shrugs off immune therapy, so researchers hunt for partners that can wake the immune system up. Tetsuya Asakawa and co-authors test a three-way combination in a 2026 mouse study. A standard drug pair that damages cancer DNA joins focused radiation and immune checkpoint blockade.
In lab dishes, the drug and radiation each forced cancer cells into an immunogenic death that spills warning signals, and together they spilled more. In mice carrying two tumors, treating one shrank the untreated one too, as killer T cells flooded in and suppressive macrophages thinned. Adding the checkpoint drug deepened the effect further. The authors argue the triple strategy deserves a clinical trial.
Catalog record
| CREATOR | Tetsuya Asakawa, Jun Kinoshita, Kenta Doden, Kengo Hayashi, Saki Hayashi, Hiroto Saito, Toshikatsu Tsuji, Daisuke Yamamoto, Hideki Moriyama, Sachiyo Nomura, Yasuhiko Yamamoto, Noriyuki Inaki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |