Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase
Sajib Kumar Sarkar, Arnab Nayek, Rashmi Minocha, Gurpreet Singh Gill, Deepak Kumar, Nidhi Bharadwaj, Om Saswat Sahoo, Prasenjit Das, Nihar Ranjan Dash, Kailash Kurdia, Abhibroto Karmakar, Ruby Dhar, Subhradip Karmakar · 2026
Read Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase by Sajib Kumar Sarkar, Arnab Nayek, Rashmi Minocha, Gurpreet Singh Gill, Deepak Kumar, Nidhi Bharadwaj, Om Saswat Sahoo, Prasenjit Das, Nihar Ranjan Dash, Kailash Kurdia, Abhibroto Karmakar, Ruby Dhar, Subhradip Karmakar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13396475.txt.
Description
Sajib Kumar Sarkar and co-authors sequenced the active genes of gallbladder cancer, a rare but fast-moving cancer of the biliary tract, to map what goes wrong inside its cells. Their 2026 study compares 13 tumors with six matched healthy samples.
The scan found 1,319 genes working at abnormal levels, 528 turned up and 791 turned down. Programs driving cell division, including E2F targets and a checkpoint before division, were switched on, while bile acid handling and estrogen response programs faded. Network analysis grouped genes into modules and named hub genes, and the Aurora kinase pathway stood out. Key candidates were checked again in patient tissue and cell lines.
Catalog record
| CREATOR | Sajib Kumar Sarkar, Arnab Nayek, Rashmi Minocha, Gurpreet Singh Gill, Deepak Kumar, Nidhi Bharadwaj, Om Saswat Sahoo, Prasenjit Das, Nihar Ranjan Dash, Kailash Kurdia, Abhibroto Karmakar, Ruby Dhar, Subhradip Karmakar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57732 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |