Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features
Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao · 2026
Read Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features by Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13396447.txt.
Description
Zihan Xu and co-authors profiled 60 cancer cell lines cell by cell. They measured both gene activity and which stretches of DNA lay open, hunting for rules that set a cancer cell's state. Their 2026 atlas spans 16 tissues of origin and 20 cancer types.
The collection holds about 241,000 gene-activity profiles and 223,000 chromatin profiles. Across that spread, the team found shared regulatory networks and one conserved axis tied to a change called EMT, where cells loosen and become mobile. Amplified control genes appeared to push cells between states. A rare skin melanoma subtype showed a shared program that damps inflammation, set against its common cousin.
Catalog record
| CREATOR | Zihan Xu, Aileen Ugurbil, Joshua Kwan, Chloe Schaefer, Abdulraouf Abdulraouf, Ziyu Lu, Erting Tang, Wei Zhou, Junyue Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96731 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |