Inter-assay and Inter-site Performance of Alpha-Synuclein Seed Amplification Assays in Synucleinopathies: A Multicenter 2 × 2 Protocol Comparison
Roger Plaza-Clar, Maximilian Weber, Vaibhavi Kadam, Christian Deuschle, Yihua Ma, Carly M. Farris, Luis Concha-Marambio, David Mengel, Marcello Rossi, Angela Mammana, Piero Parchi, Matthis Synofzik, Kathrin Brockmann, Thomas Gasser · 2026
Read Inter-assay and Inter-site Performance of Alpha-Synuclein Seed Amplification Assays in Synucleinopathies: A Multicenter 2 × 2 Protocol Comparison by Roger Plaza-Clar, Maximilian Weber, Vaibhavi Kadam, Christian Deuschle, Yihua Ma, Carly M. Farris, Luis Concha-Marambio, David Mengel, Marcello Rossi, Angela Mammana, Piero Parchi, Matthis Synofzik, Kathrin Brockmann, Thomas Gasser (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13396297.txt.
Description
Roger Plaza-Clar and others weigh two seed-growth tests for Parkinson-type illness across labs in a 2026 multi-site study. This seed test spots Parkinson-type illness, and test brews may sort Lewy-body illness from glial-inclusion illness, but head-to-head test proof was thin.
In a tight two-by-two plan, two brew kinds each ran at two free labs. Spine fluid came from 60 people, with system atrophy cases plus Parkinson and Lewy dementia cases in the mix. The study scores match and illness sorting across brews and sites. Doctors gain a firm base for picking and reading these seed tests.
Catalog record
| CREATOR | Roger Plaza-Clar, Maximilian Weber, Vaibhavi Kadam, Christian Deuschle, Yihua Ma, Carly M. Farris, Luis Concha-Marambio, David Mengel, Marcello Rossi, Angela Mammana, Piero Parchi, Matthis Synofzik, Kathrin Brockmann, Thomas Gasser |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |