Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing
Benhao Li, Mengyao Zhao, Bowei Yang, Taihua Yang, Yongling Wang, Yaxin Hu, Miao Zhang, Jiahao Ge, Xianglong Tang, Ze Zhang, Hengqing Cui, Xiaoyuan Chen, Yi Yan Yang, Ling Peng, Qianqian Ni · 2026
Read Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing by Benhao Li, Mengyao Zhao, Bowei Yang, Taihua Yang, Yongling Wang, Yaxin Hu, Miao Zhang, Jiahao Ge, Xianglong Tang, Ze Zhang, Hengqing Cui, Xiaoyuan Chen, Yi Yan Yang, Ling Peng, Qianqian Ni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13396230.txt.
Description
Li and co-authors design, in 2026, antioxidant lipid nanoparticles that protect messenger RNA from oxidative damage in injured tissue. mRNA medicines degrade quickly where reactive oxygen species abound, exactly the setting of wounds and inflamed organs. The team built a library of 64 antioxidant ionizable lipids, screened them, and landed on a lead particle, AO12LNP, whose lipid carries a 4-hydroxyphenyl group that scavenges reactive species.
Under oxidative stress, the lead particles scored 89 percent on the study's antioxidation measure, against 57 percent for a standard-style particle based on the lipid SM-102. The particles stayed uniform at roughly 150 nanometers across and packed over 80 percent of their mRNA cargo. Across several organ and tissue injury models, the antioxidant particles sustained stronger, longer protein expression and better preserved transcript integrity than conventional particles. That improved regeneration outcomes and genome editing efficiency in the reported experiments.
Catalog record
| CREATOR | Benhao Li, Mengyao Zhao, Bowei Yang, Taihua Yang, Yongling Wang, Yaxin Hu, Miao Zhang, Jiahao Ge, Xianglong Tang, Ze Zhang, Hengqing Cui, Xiaoyuan Chen, Yi Yan Yang, Ling Peng, Qianqian Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |