Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism
Matthew Pun, Akash Deogharkar, Siva Kumar Natarajan, Nicholas Nuechterlein, Wentao Tian, Sunjong Ji, Eleanor Young, Fusheng Yang, Debra Hawes, Anthony C. Andren, John Henry Owen, Sagar Rau, Fengyun Su, Xuhong Cao, Abhijit Parolia, Mark Prince, Joshua Fry, Paul A. Gardner, Rendong Yang, Alexander R. Judkins, Carl J. Koschmann, Andrew S. Venteicher, Costas A. Lyssiotis, Arul M. Chinnaiyan, Sriram Venneti · 2026
Read Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism by Matthew Pun, Akash Deogharkar, Siva Kumar Natarajan, Nicholas Nuechterlein, Wentao Tian, Sunjong Ji, Eleanor Young, Fusheng Yang, Debra Hawes, Anthony C. Andren, John Henry Owen, Sagar Rau, Fengyun Su, Xuhong Cao, Abhijit Parolia, Mark Prince, Joshua Fry, Paul A. Gardner, Rendong Yang, Alexander R. Judkins, Carl J. Koschmann, Andrew S. Venteicher, Costas A. Lyssiotis, Arul M. Chinnaiyan, Sriram Venneti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13396039.txt.
Description
Matthew Pun and co-authors found a metabolic weak point in chordoma, a rare cancer that grows along the spine and skull base, and reported it in 2026. Looking for enzymes the tumors lean on, they landed on IDH1, a protein that helps run the cell's energy cycle and keeps its chemistry balanced.
IDH1 was abundant in patient tumor samples, both in bulk tests and single-cell data, and high levels tracked with worse survival. Blocking the enzyme, either by silencing its gene or with a drug, killed chordoma cells in the lab. Follow-up profiling of genes, chromatin, and metabolites showed the damage runs through the cell's handling of oxidative stress.
Catalog record
| CREATOR | Matthew Pun, Akash Deogharkar, Siva Kumar Natarajan, Nicholas Nuechterlein, Wentao Tian, Sunjong Ji, Eleanor Young, Fusheng Yang, Debra Hawes, Anthony C. Andren, John Henry Owen, Sagar Rau, Fengyun Su, Xuhong Cao, Abhijit Parolia, Mark Prince, Joshua Fry, Paul A. Gardner, Rendong Yang, Alexander R. Judkins, Carl J. Koschmann, Andrew S. Venteicher, Costas A. Lyssiotis, Arul M. Chinnaiyan, Sriram Venneti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76128 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |