NAD⁺ biology and supplementation: From mechanisms to clinical perspectives
Sergio Pandolfi, Charlye Ghezzi, Geir Björklund, Marco Metalla, Francesco Maria Paone, Salvatore Chirumbolo · 2026
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Description
Sergio Pandolfi and colleagues combined a literature review with mathematical modelling in a 2026 article on NAD+, a molecule cells need for energy use, repair, and signals tied to aging. Supplements that supply building blocks for NAD+ have become popular, yet proof of benefit is uneven.
Oral precursors such as nicotinamide riboside and nicotinamide mononucleotide can raise blood NAD+ levels, though gains differ by person and setting. Giving NAD+ by vein is far less studied and lacks strong clinical support. The modelling shows responses that bend rather than rise in a straight line, shaped by dose, age, body state, and route. The authors urge care in reading current claims and call for better trials.
Catalog record
| CREATOR | Sergio Pandolfi, Charlye Ghezzi, Geir Björklund, Marco Metalla, Francesco Maria Paone, Salvatore Chirumbolo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106979 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |