The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma · 2026
Read The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance by Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13395749.txt.
Description
Yuwei Li and co-authors find, in 2026, a guard that keeps myelin-making cells safe from rust-like death. Cells that wrap nerves face heavy strain as they build fatty sheaths. A tagging enzyme named RLIM marks a cystine porter for keeping at the cell surface. That porter feeds production of glutathione, a master shield.
Mice lacking RLIM in these cells lost porter from the surface, made fewer cells, and formed poor myelin. Their movement, social acts, and thinking slipped in ways that echo human cases. Most harmful human variants broke the porter grip. Extra glutathione rescued mice in the tests. The authors pitch the shield as a therapy lead.
Catalog record
| CREATOR | Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98535 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |