Platelet membrane biomimetic nanoparticle-based targeted delivery system of simvastatin for the treatment of ischemic stroke
Qin Li, Rongyuan Li, Lu Lin, Meiting Gong, Yu Liang, Daming Sui · 2026
Read Platelet membrane biomimetic nanoparticle-based targeted delivery system of simvastatin for the treatment of ischemic stroke by Qin Li, Rongyuan Li, Lu Lin, Meiting Gong, Yu Liang, Daming Sui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13395312.txt.
Description
Qin Li and co-authors build, in 2026, a platelet-cloaked carrier to ferry a statin into stroke-damaged brain. Simvastatin can mend the blood-brain barrier and calm swelling, but it crosses poorly and needs high doses. The team wrapped drug-loaded cores in platelet skins, which home to injured vessels. Tests ran in stressed nerve cells, immune cells, and stroked animals.
The cloaked particles cleared harmful radicals and nudged immune cells toward a healing mode. In animals they shrank the dead brain zone far more than free drug. Movement and sense recovered faster over three weeks, and weight loss eased. The authors pitch the cloak as a lower-dose route to lasting brain guard.
Catalog record
| CREATOR | Qin Li, Rongyuan Li, Lu Lin, Meiting Gong, Yu Liang, Daming Sui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38097 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |