Clonal drift in the aging gut: Mapping the fate of stem cells over time
Tzu-Chiao Lu, Hongjie Li · 2026
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Description
Tzu-Chiao Lu and Hongjie Li comment, in 2026, on a study that tracks stem cell families in the ageing fly gut. Young guts hold a wide, mixed pool of stem cells. Over life that pool narrows, a drift long known in blood but hard to film in a living organ. The new study reads mutation barcodes that daughter cells inherit and add to.
With those barcodes, models judged which families last and which fade. Loss of families struck early in life, not just in old age. Early-born lines were more likely to persist and spread. The fruit fly gut offers a fast window on human gut ageing. The authors frame the work as a map for later studies.
Catalog record
| CREATOR | Tzu-Chiao Lu, Hongjie Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7947 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |