Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold · 2026
Read Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome by Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13395050.txt.
Description
Thomas Harman and co-authors test, in 2026, cannabidiol in a mouse model of Lennox-Gastaut syndrome, a severe child epilepsy. The mice carry a gene change that brings odd absence seizures and body spasms. Brain wave recordings counted both event types. Adults got single doses of three drugs, and pups got daily doses over three days.
Only the altered mice had the absence seizures, and all three drugs cut them. Pups with the gene change spasmed more than normal pups. Cannabidiol and vigabatrin both cut spasm counts. The authors back the mouse as a sound test bed for new drugs. Cannabidiol helped both seizure types, which lifts interest in plant-based drugs.
Catalog record
| CREATOR | Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37559 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |