VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz · 2026
Read VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption by Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13394815.txt.
Description
Karla B. Neves and co-authors trace, in 2026, how some cancer drugs harm blood vessels. The drugs block a growth signal that tumours use to build vessels, but they can raise blood pressure and stiffen vessels. Tests used a drug named axitinib on human vessel cells and on mouse arteries. The team watched stress chemicals, repair enzymes, and vessel squeeze.
Axitinib raised harmful oxygen radicals and switched on a repair enzyme named PARP. A second enzyme, SIRT1, lost ground, and vessel lining signals soured. Blocking PARP or boosting SIRT1 restored vessel calm in the tests. Swelling markers and sticky vessel walls also eased. The authors suggest these levers could guard patients during cancer care.
Catalog record
| CREATOR | Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40636 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |