Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow
Amaia Ochandorena-Saa, Emeline Perthame, Zoé Oulerich, Alexander Chamolly, Thierry Blisnick, Johanna Lokmer, Cécile Rouillon, Philippe Bastin, Sigolène M. Meilhac · 2026
Read Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow by Amaia Ochandorena-Saa, Emeline Perthame, Zoé Oulerich, Alexander Chamolly, Thierry Blisnick, Johanna Lokmer, Cécile Rouillon, Philippe Bastin, Sigolène M. Meilhac (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13394393.txt.
Description
Amaia Ochandorena-Saa and colleagues report, in 2026, how mice set left and right sides without the usual flow cue. In normal embryos, tiny hairs sweep fluid left in a pit called the node, and that flow guides organ layout. The team studied mutant mice whose hairs cannot move. To their surprise, most pups were born with organs in the normal places.
Gene studies pointed to two signal sets, Wnt and Nodal, sorting embryos into layout groups. Some mutants showed a fully mirrored body, and some showed mixed layouts with heart and lung faults. Drugs that nudge Wnt backed its role. The authors propose that flow only biases a choice the embryo can make alone.
Catalog record
| CREATOR | Amaia Ochandorena-Saa, Emeline Perthame, Zoé Oulerich, Alexander Chamolly, Thierry Blisnick, Johanna Lokmer, Cécile Rouillon, Philippe Bastin, Sigolène M. Meilhac |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90000 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |