Engineered probiotic Bifidobacterium for tumor-targeted pancreatic cancer therapy
Jaehyun Lee, Kaiting Yang, Christina A. Nowicki, Wei Liu, Kangdi Li, Emile Naccasha, Zhichen Sun, Yang-Xin Fu, Hua Liang, Ralph R. Weichselbaum, Mark Mimee · 2026
Read Engineered probiotic Bifidobacterium for tumor-targeted pancreatic cancer therapy by Jaehyun Lee, Kaiting Yang, Christina A. Nowicki, Wei Liu, Kangdi Li, Emile Naccasha, Zhichen Sun, Yang-Xin Fu, Hua Liang, Ralph R. Weichselbaum, Mark Mimee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13394381.txt.
Description
Jaehyun Lee and colleagues describe, in 2026, a friendly gut germ reshaped to fight pancreatic cancer in mice. The germ settles in tumours, where oxygen is low, and makes a tuned form of interleukin-2. That signal wakes up killer T cells more than the cells that calm them down. Plain interleukin-2 fades fast and can harm the whole body, so local delivery matters.
Given to mice, the germ slowed both skin tumours and tumours grown in the pancreas. It also worked better when paired with chemo, radiation, or other immune drugs. The authors offer the approach as a route into cancers that shrug off standard care.
Catalog record
| CREATOR | Jaehyun Lee, Kaiting Yang, Christina A. Nowicki, Wei Liu, Kangdi Li, Emile Naccasha, Zhichen Sun, Yang-Xin Fu, Hua Liang, Ralph R. Weichselbaum, Mark Mimee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58734 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |