Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts
Toan Pham · 2026
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Description
Toan Pham dissected heart muscle from type 2 diabetic rats to find why its mitochondria, the cell's power stations, falter, testing the parts separately on carbohydrate and fatty acid fuels. Metabolite profiling by mass spectrometry ran beside measures of respiration, energy flux, corrosive oxygen output, and membrane voltage in heart tissue. Diabetes was expected to blunt everything, but the defect proved choosy.
On carbohydrate fuel, diabetic mitochondria breathed, produced energy, and held voltage as well as healthy ones. On fatty acids, respiration and energy flux dropped sharply even though the muscle was swimming in fatty acid species, several of them plainly piled up. Krebs cycle intermediates barely moved. Pham reads the pattern as metabolic inflexibility: fuel oversupply unmatched by burning capacity, wasting energy promise in the diabetic heart.
Catalog record
| CREATOR | Toan Pham |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39817 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |