In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology
Qiu Jiang, Jian-Ni Hu, Hao-Min Dong, Jia-Yan Xin, An-Yu Shi, Gui-Hua Zeng, Jie Liu, Yan-Jiang Wang · 2026
Read In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology by Qiu Jiang, Jian-Ni Hu, Hao-Min Dong, Jia-Yan Xin, An-Yu Shi, Gui-Hua Zeng, Jie Liu, Yan-Jiang Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13393950.txt.
Description
Qiu Jiang and co-authors chart in 2026 the proteins that astrocytes secrete across brain regions in a mouse model of Alzheimer's amyloid buildup. Brain cells coordinate through such secreted signals, and broken talk between astrocytes and neurons is tied to the disease. The map of that talk was largely missing.
The team tagged secreted proteins inside living mice with a proximity labeling trick, then read them by region and time. In the entorhinal cortex, a region hit early, the changes clustered in metabolic pathways. Other regions showed their own patterns. Region specific maps explain why the disease strikes areas in sequence. They also expose signals that might be boosted or blocked to slow it.
Catalog record
| CREATOR | Qiu Jiang, Jian-Ni Hu, Hao-Min Dong, Jia-Yan Xin, An-Yu Shi, Gui-Hua Zeng, Jie Liu, Yan-Jiang Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |