Mycoplasma pneumoniae infection impairs asthma control in pediatric patients and exacerbates allergic airway inflammation
Chao Yan, Xinyu Jia, Xue Ren, Yujie Chen, Xuanfeng Liu, An Su, Bing Du, Hanqing Zhao, Yanling Feng, Guanhua Xue, Jinghua Cui, Yuehua Ke, Lin Gan, Junxia Feng, Zheng Fan, Tongtong Fu, Ziying Xu, Zihui Yu, Yang Yang, Tingting Zhang, Jing Yuan · 2026
Read Mycoplasma pneumoniae infection impairs asthma control in pediatric patients and exacerbates allergic airway inflammation by Chao Yan, Xinyu Jia, Xue Ren, Yujie Chen, Xuanfeng Liu, An Su, Bing Du, Hanqing Zhao, Yanling Feng, Guanhua Xue, Jinghua Cui, Yuehua Ke, Lin Gan, Junxia Feng, Zheng Fan, Tongtong Fu, Ziying Xu, Zihui Yu, Yang Yang, Tingting Zhang, Jing Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393913.txt.
Description
Chao Yan leads a twenty-one-author study of how Mycoplasma pneumoniae infection weakens asthma control in children. Clinical records covered one hundred forty-five children with asthma. The team layered in microbe detection, drug sensitivity work, and metabolite profiling. They then mirrored the question in allergic mice with and without the infection. The clinical signal was clear: children carrying the bacterium alongside asthma were much likelier to have poorly controlled disease.
The infecting strains in positive samples shared one genotype and all carried a mutation known to blunt macrolide antibiotics. In mice the infection worsened allergic symptoms, airway twitchiness, allergy marker levels, and lung tissue damage scores. Gene reads showed shifted airway microbes and altered signals and metabolite patterns. The authors say the joined evidence supports screening and tailored care when the two coincide.
Catalog record
| CREATOR | Chao Yan, Xinyu Jia, Xue Ren, Yujie Chen, Xuanfeng Liu, An Su, Bing Du, Hanqing Zhao, Yanling Feng, Guanhua Xue, Jinghua Cui, Yuehua Ke, Lin Gan, Junxia Feng, Zheng Fan, Tongtong Fu, Ziying Xu, Zihui Yu, Yang Yang, Tingting Zhang, Jing Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49681 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |