Kaempferol-modified mesenchymal stem cell extracellular vesicle-mimetics promote photoaging repair by suppressing ADAM10
Nan Fu, Huan Zhang, Xianhao Shi, Xian Xiao, Xiaoxia Li, Ping Song, Shihua Wang, Robert Chunhua Zhao · 2026
Read Kaempferol-modified mesenchymal stem cell extracellular vesicle-mimetics promote photoaging repair by suppressing ADAM10 by Nan Fu, Huan Zhang, Xianhao Shi, Xian Xiao, Xiaoxia Li, Ping Song, Shihua Wang, Robert Chunhua Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13393870.txt.
Description
Nan Fu and colleagues engineer stem cell vesicle mimics loaded with kaempferol to repair sun-aged skin in a 2026 study. Chronic ultraviolet B exposure drives oxygen radicals, inflammation, and breakdown of skin matrix, while natural stem cell vesicles are hard to produce at scale.
The team built high-yield vesicle mimics preserving vesicle activity, then loaded them with kaempferol, a natural blocker of the matrix-degrading enzyme ADAM10. Treated skin cells showed less radical damage, DNA harm, and senescence, with restored enzyme balance. The paper offers a scalable platform for photoaging repair.
Catalog record
| CREATOR | Nan Fu, Huan Zhang, Xianhao Shi, Xian Xiao, Xiaoxia Li, Ping Song, Shihua Wang, Robert Chunhua Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |