Point-of-care hrHPV mRNA detection with reverse transcription recombinase polymerase amplification on a portable fluorimeter from provider-collected cervical samples in Maputo, Mozambique
Emilie Newsham Novak, Cannon J. Hansen, Zoha Wazir, Ariel Ma, Jennifer Carns, Hira Atif, Jane R. Montealegre, Michael E. Scheurer, Cesaltina Lorenzoni, Daniel G. Rosen, Mila P. Salcedo, Kathleen M. Schmeler, Rebecca R. Richards-Kortum · 2026
Read Point-of-care hrHPV mRNA detection with reverse transcription recombinase polymerase amplification on a portable fluorimeter from provider-collected cervical samples in Maputo, Mozambique by Emilie Newsham Novak, Cannon J. Hansen, Zoha Wazir, Ariel Ma, Jennifer Carns, Hira Atif, Jane R. Montealegre, Michael E. Scheurer, Cesaltina Lorenzoni, Daniel G. Rosen, Mila P. Salcedo, Kathleen M. Schmeler, Rebecca R. Richards-Kortum (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393838.txt.
Description
Emilie Newsham Novak leads a thirteen-author pilot in Maputo, Mozambique, testing a portable point-of-care assay for high-risk HPV messenger RNA as a sharper cervical cancer screen. Cervical cancer is the commonest cancer in Mozambican women, and DNA testing's weak specificity drives overtreatment in screen-and-treat programmes. Twenty-two women who had screened positive by visual inspection gave samples for the new test, run on a portable fluorimeter with bench methods adapted to low-resource kit.
The rapid amplification test agreed completely with the laboratory gold standard across all samples and finished in about a third of the time. Every positive on the new test matched the commercial DNA test by type, and the new test predicted high-grade biopsy lesions more precisely, though it missed more negatives. The authors call the approach feasible and ask for larger studies.
Catalog record
| CREATOR | Emilie Newsham Novak, Cannon J. Hansen, Zoha Wazir, Ariel Ma, Jennifer Carns, Hira Atif, Jane R. Montealegre, Michael E. Scheurer, Cesaltina Lorenzoni, Daniel G. Rosen, Mila P. Salcedo, Kathleen M. Schmeler, Rebecca R. Richards-Kortum |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24660 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |