Lens tissue transcriptome analysis in patients with total congenital cataract
Xiaolei Lin, Huiyu Chen, Xin Liu, Fan Fan, Yulan Wang, Yi Luo · 2026
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Description
Xiaolei Lin and colleagues map gene activity in lenses from children with total congenital cataract in a 2026 transcriptome study. This condition is a leading cause of childhood visual impairment, and its molecular drivers were incompletely known.
Comparing lens surface cells and fiber cells, the team found 1,645 altered genes in surface cells and 2,708 in fiber cells, pointing to matrix organization and protein targeting pathways. Five lens-enriched candidate genes, including HOPX and SUSD2, were markedly reduced in both cell types. The work nominates new genes behind lens development, oxidative stress, and cell death.
Catalog record
| CREATOR | Xiaolei Lin, Huiyu Chen, Xin Liu, Fan Fan, Yulan Wang, Yi Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |