A Novel Entity of Renal Toxicity After Combination Chemotherapy: An Onco-Nephrology Kidney Biopsy Teaching Case
Gian Marco Berti, Federica Maritati, Francesco Tondolo, Stefano Chilotti, Benedetta Fabbrizio, Gianandrea Pasquinelli, Gaetano La Manna, Gisella Vischini · 2026
Read A Novel Entity of Renal Toxicity After Combination Chemotherapy: An Onco-Nephrology Kidney Biopsy Teaching Case by Gian Marco Berti, Federica Maritati, Francesco Tondolo, Stefano Chilotti, Benedetta Fabbrizio, Gianandrea Pasquinelli, Gaetano La Manna, Gisella Vischini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393669.txt.
Description
Gian Marco Berti leads an eight-author teaching case of kidney damage after combination chemotherapy that assembled into a pattern never before reported in this setting. A 65-year-old woman with returning high-grade Müllerian cancer developed failing kidneys, rising blood pressure, and new protein in the urine while receiving carboplatin, gemcitabine, and bevacizumab. Blood tests excluded autoimmune, viral, and blood disorders, leaving the drugs in the frame.
Kidney biopsy showed a membranoproliferative pattern with capillary deposits, widespread vessel lining injury, and odd fat-like figures inside tubules. Two weeks later skin purpura reframed the picture, and fine structural study revealed organised immune deposits fitting drug-induced cryoglobulin disease layered over chronic small-vessel injury from gemcitabine, plus unexpected kidney fat storage. The authors stress biopsy's role in untangling cancer drug injury.
Catalog record
| CREATOR | Gian Marco Berti, Federica Maritati, Francesco Tondolo, Stefano Chilotti, Benedetta Fabbrizio, Gianandrea Pasquinelli, Gaetano La Manna, Gisella Vischini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19670 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |