Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells
Tianyi Yang, Jung-Sik Kim, Clara Mellows, Wanying Xu, Alvin Ya, Lisa Sadzewicz, Luke Tallon, Jann Sarkaria, Fulai Jin, Todd Waldman · 2026
Read Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells by Tianyi Yang, Jung-Sik Kim, Clara Mellows, Wanying Xu, Alvin Ya, Lisa Sadzewicz, Luke Tallon, Jann Sarkaria, Fulai Jin, Todd Waldman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13393664.txt.
Description
Tianyi Yang and nine colleagues restored the tumour suppressor STAG2 in human cancer cells and watched the genome's three-dimensional loops shrink rapidly across the board. STAG2, part of the cohesin ring that folds chromosomes, is lost in many cancers including bladder tumours, brain tumours, and leukaemias, yet how its loss drives cancer has stayed murky. Acute reconstitution offered a clean before-and-after view.
Despite the global loop change, few genes changed expression early, and most of those switched on. One gene, encoding the growth-suppressing matrix protein fibulin-3, rose in every model. The most robust responders sat inside intense loops whose anchors and strength did not budge, a puzzle the authors note. They propose that losing STAG2 removes a size limit on loops, widening chromatin contacts until the tumour-suppressive programme can no longer hold.
Catalog record
| CREATOR | Tianyi Yang, Jung-Sik Kim, Clara Mellows, Wanying Xu, Alvin Ya, Lisa Sadzewicz, Luke Tallon, Jann Sarkaria, Fulai Jin, Todd Waldman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38469 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |