Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae
Chudai Zeng, Fei Gao, Mei Hu, Jian Zhang, Dexiao Zhu, Li Sun, Jianlu Lyu, Mingzhe Pan, Chu Chen · 2026
Read Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae by Chudai Zeng, Fei Gao, Mei Hu, Jian Zhang, Dexiao Zhu, Li Sun, Jianlu Lyu, Mingzhe Pan, Chu Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13393616.txt.
Description
Chudai Zeng and colleagues study a brain lipid pathway that may calm epilepsy damage in a 2026 mouse study. Temporal lobe epilepsy, the most common focal epilepsy, drives toxic overexcitation, inflammation, nerve cell loss, and memory decline, and current drugs often fall short.
The team used a kainic acid model of prolonged seizures in mice with normal, astrocyte-specific, and neuron-specific loss of the enzyme MAGL, which breaks down the protective lipid 2-AG. Blocking that breakdown reprogrammed star-shaped brain support cells and limited seizure aftermath. The work points researchers toward cell-specific targets for protecting the epileptic brain.
Catalog record
| CREATOR | Chudai Zeng, Fei Gao, Mei Hu, Jian Zhang, Dexiao Zhu, Li Sun, Jianlu Lyu, Mingzhe Pan, Chu Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |